bio-causal-genomics-proteome-mr-drug-target

bio-causal-genomics-proteome-mr-drug-target is a Bioinformatics & life sciences skill for AI agents, published by GPTomics in the bioSkills repository on GitHub. Skillspace rates bio-causal-genomics-proteome-mr-drug-target D (60/100) and it passed the safety scan; the rating is based on static analysis only.

Runs cis-pQTL Mendelian randomization for drug-target validation using UKB-PPP (Olink), deCODE (SomaScan), Fenland, INTERVAL, ARIC, and FinnGen-PPP proteomes plus colocalization triangulation, phenome-wide on-target adverse-effect scans, cross-platform Olink/SomaScan replication, and PAV (protein-altering variant) sensitivity. Use when nominating or de-risking a drug target from plasma-proteome GWAS, mimicking pharmacological inhibition via cis-pQTL instruments, separating shared-causal from LD-confounded signal under the Schmidt 2020 cis-MR framework, screening on-target adverse phenotypes pheWAS-style, or producing publication-grade STROBE-MR plus PP.H4 evidence for a target gene.

Grade
D
Quality
60 / 100
Safety
Passed
GitHub stars
1,202

Unproven: rated by static analysis only, not yet compared head-to-head.

This rating describes the version of the repository we crawled; it may have changed since, so go by its current files.

View source on GitHubGPTomics/bioSkills

Our review

Architecture
93 / 100
Maturity
Basic: a single SKILL.md
Security scan
Low-risk patterns
License
Not declared. Check the repository before reusing it.

What the scanner flagged

  • mentions secrets in text

Not checked yet

  • Category is a classifier prediction; no model has read this skill yet
  • Not judged on the rubric yet (not a contender in its category)
  • No blind task eval yet
  • Scope (portable / vendor / repo-internal) not assessed; only the top of each category is read for scope
  • Sibling files (scripts, references) not fetched; security scan covers SKILL.md only

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Also published in 1 other repo

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