design-base-editor-sgrnas

design-base-editor-sgrnas is a Bioinformatics & life sciences skill for AI agents, published by MDhewei in the bioinfor-claw repository on GitHub. Skillspace rates design-base-editor-sgrnas B (81/100) and it passed the safety scan; the rating is based on static analysis only.

Design base editor sgRNAs for a given gene. Fetches exonic sequence from Ensembl, scans for all NGG (or NG/NGA) PAM sites, filters for guides where a cytosine (CBE) or adenine (ABE) falls in the editing window, scores guides for efficiency and bystander risk, and returns a ranked table. Supports CBE (C→T), ABE (A→G), and dual-base editors for human, mouse, and monkey.

Grade
B
Quality
81 / 100
Safety
Passed
GitHub stars
63

Unproven: rated by static analysis only, not yet compared head-to-head.

This rating describes the version of the repository we crawled; it may have changed since, so go by its current files.

View source on GitHubMDhewei/bioinfor-claw

Our review

Architecture
100 / 100
Maturity
Structured: ships references or scripts
Security scan
No issues found
License
MIT
Adoption
Adopted by 0 other repositories, in 0 collections

Not checked yet

  • Not judged on the rubric yet (not a contender in its category)
  • No blind task eval yet
  • Scope (portable / vendor / repo-internal) not assessed; only the top of each category is read for scope
  • Sibling files (scripts, references) not fetched; security scan covers SKILL.md only

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