esmfold2
esmfold2 is a Chemistry & materials skill for AI agents, published by aipoch in the open-science repository on GitHub. Skillspace rates esmfold2 F (45/100) and the safety scan rated it risky; the rating is based on static analysis only.
Risky. This skill has patterns associated with unsafe behaviour. Read the source carefully before running it.
Biohub ESMFold2 / ESMFold2-Fast all-atom co-folding (Candido et al. 2026, github.com/Biohub/esm). Single-sequence and MSA modes; protein, DNA, RNA, ligand (CCD/SMILES), modified residues. FoldBench Ab-Ag 50-55%, PPI 70-77% DockQ-pass. Also covers the ESMC-{300M,600M,6B} protein language models from the same release: masked-LM logits, hidden states, mutation scoring, contact prediction, and the SAE interpretability head. MIT-licensed weights on HuggingFace org `biohub`. Use this skill when: (1) Predicting complex structures with single-sequence input, (2) Validating designed binders with ESMFold2-Fast, (3) Running ESMFold2 with MSA input, (4) Getting ESMC embeddings or per-residue mutation scores, (5) Choosing kernel backend and sampling-step settings for paper-faithful throughput.
- Grade
- F
- Quality
- 45 / 100
- Safety
- Risky
- GitHub stars
- 4,174
Unproven: rated by static analysis only, not yet compared head-to-head.
Our two independent classifiers differ on this skill's category, so treat the placement as provisional.
This rating describes the version of the repository we crawled; it may have changed since.
Our review
- Architecture
- 84 / 100
- Maturity
- Basic: a single SKILL.md
- Security scan
- High-risk patterns
- License
- Not declared. Check the repository before reusing it.
What the scanner flagged
- dynamic code execution (eval/exec)
- mentions secrets in text
Not checked yet
- Category is a classifier prediction; no model has read this skill yet
- Not judged on the rubric yet (not a contender in its category)
- No blind task eval yet
- Scope (portable / vendor / repo-internal) not assessed; only the top of each category is read for scope
- Sibling files (scripts, references) not fetched; security scan covers SKILL.md only
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