rfdiffusion

rfdiffusion is a Bioinformatics & life sciences skill for AI agents, published by adaptyvbio in the protein-design-skills repository on GitHub. Skillspace rates rfdiffusion C (72/100) and it passed the safety scan; the rating is based on static analysis only.

Generate protein backbones using RFdiffusion, a diffusion-based generative model for de novo protein structure generation. Use this skill when: (1) Designing binder scaffolds for a target protein, (2) Generating novel protein backbones from scratch, (3) Scaffolding functional motifs into new proteins, (4) Specifying hotspot residues for interface design, (5) Creating symmetric oligomers. For sequence design after backbone generation, use proteinmpnn. For structure validation, use alphafold or chai. For QC thresholds, use protein-qc.

Grade
C
Quality
72 / 100
Safety
Passed
GitHub stars
147

Unproven: rated by static analysis only, not yet compared head-to-head.

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Our review

Architecture
84 / 100
Maturity
Packaged: licensed, with a version or references
Security scan
No issues found
License
MIT
Adoption
Adopted by 0 other repositories, in 0 collections

Not checked yet

  • Not judged on the rubric yet (not a contender in its category)
  • No blind task eval yet
  • Scope (portable / vendor / repo-internal) not assessed; only the top of each category is read for scope
  • Sibling files (scripts, references) not fetched; security scan covers SKILL.md only

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